Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types.

ABSTRACT: Aging is a complex process involving transcriptomic changes associated with deterioration across multiple tissues and organs, including the brain. Recent studies using heterochronic parabiosis have shown that various aspects of aging-associated decline are modifiable or even reversible. To better understand how this occurs, we performed single-cell transcriptomic profiling of young and old mouse brains after parabiosis. For each cell type, we cataloged alterations in gene expression, molecular pathways, transcriptional networks, ligand-receptor interactions and senescence status. Our analyses identified gene signatures, demonstrating that heterochronic parabiosis regulates several hallmarks of aging in a cell-type-specific manner. Brain endothelial cells were found to be especially malleab

SUBMITTER: Ximerakis M 

PROVIDER: S-EPMC10154248 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature