Fetal growth restriction followed by very preterm birth is associated with smaller kidneys but preserved kidney function in adolescence.

ABSTRACT:

Background

Preterm birth and fetal growth restriction (FGR) are associated with structural and functional kidney changes, increasing long-term risk for chronic kidney disease and hypertension. However, recent studies in preterm children are conflicting, indicating structural changes but normal kidney function. This study therefore assessed kidney structure and function in a cohort of adolescents born very preterm with and without verified FGR.

Methods

Adolescents born very preterm with FGR and two groups with appropriate birthweight (AGA) were included; one matched for gestational week at birth and one born at term. Cortical and medullary kidney volumes and T1 and T2* mapping values were assessed by magnetic resonance imaging. Biochemical markers of kidney function and renin

SUBMITTER: Liefke J 

PROVIDER: S-EPMC10154253 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature