Kidney tubular injury induced by valproic acid: systematic literature review.

ABSTRACT:

Background

Valproic acid is prescribed for epilepsy and as prophylaxis for bipolar disorder and migraine headaches. It has also been implicated as a cause of a kidney tubular injury.

Methods

We undertook a review of the literature to characterize the biochemical and histopathological features of the overt kidney tubular injury and to evaluate the possible existence of a pauci-symptomatic injury. The pre-registered review (CRD42022360357) was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. Searches were conducted in Excerpta Medica, the National Library of Medicine, and Web of Science. The gray literature was also considered.

Results

For the final analysis, we retained 36 articles: 28 case reports documen

SUBMITTER: Anguissola G 

PROVIDER: S-EPMC10154265 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature