Normative values of renin and aldosterone in clinically stable preterm neonates.

ABSTRACT:

Background

There is a paucity of literature on the normative levels of plasma renin concentration (PRC) and serum aldosterone (SA) in premature neonates. This study aims to provide normative data on PRC and SA levels in preterm neonates in the first 2 weeks after birth and explore associations with maternal, perinatal, or postnatal factors.

Methods

Neonates born at 26- to 34-week gestation were recruited from two neonatal intensive care units in Canada and Australia. The direct renin assay PRC and SA were analyzed on day 1 and days 14-21 after birth to compare across categorical variables and to produce normative values.

Results

A total of 262 subjects were enrolled from the Canadian (29%) and Australian (71%) sites. The mean gestational age was 30 weeks, with a mean

SUBMITTER: Xu JH 

PROVIDER: S-EPMC10154272 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature