Heritability Estimation of Cognitive Phenotypes in the ABCD Study^® Using Mixed Models.

ABSTRACT: Twin and family studies have historically aimed to partition phenotypic variance into components corresponding to additive genetic effects (A), common environment (C), and unique environment (E). Here we present the ACE Model and several extensions in the Adolescent Brain Cognitive Development℠ Study (ABCD Study^®), employed using the new Fast Efficient Mixed Effects Analysis (FEMA) package. In the twin sub-sample (n = 924; 462 twin pairs), heritability estimates were similar to those reported by prior studies for height (twin heritability = 0.86) and cognition (twin heritability between 0.00 and 0.61), respectively. Incorporating SNP-derived genetic relatedness and using the full ABCD Study^® sample (n = 9,742) led to narrower confidence intervals for all parameter est

SUBMITTER: Smith DM 

PROVIDER: S-EPMC10154273 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature