Associations of stress and stress-related psychiatric disorders with GrimAge acceleration: review and suggestions for future work.

ABSTRACT: The notion of "biological aging" as distinct from chronological aging has been of increasing interest in psychiatry, and many studies have explored associations of stress and psychiatric illness with accelerated biological aging. The "epigenetic clocks" are one avenue of this research, wherein "biological age" is estimated using DNA methylation data from specific CpG dinucleotide sites within the human genome. Many iterations of the epigenetic clocks have been developed, but the GrimAge clock continues to stand out for its ability to predict morbidity and mortality. Several studies have now explored associations of stress, PTSD, and MDD with GrimAge acceleration (GrimAA). While stress, PTSD, and MDD are distinct psychiatric entities, they may share common mechanisms underlying accelerated

SUBMITTER: Protsenko E 

PROVIDER: S-EPMC10154294 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature