Neurogenic timing of the inferior olive subdivisions is related to the olivocerebellar projection topography.

ABSTRACT: The olivocerebellar projection is organized into an intricate topographical connection from the inferior olive (IO) subdivisions to the longitudinally-striped compartments of cerebellar Purkinje Cells (PCs), to play an essential role in cerebellar coordination and learning. However, the central mechanisms for forming topography need to be clarified. IO neurons and PCs are generated during overlapping periods of a few days in embryonic development. Therefore, we examined whether their neurogenic timing is specifically involved in the olivocerebellar topographic projection relationship. First, we mapped neurogenic timing in the entire IO by using the neurogenic-tagging system of neurog2-CreER (G2A) mice and specific labeling of IO neurons with FoxP2. IO subdivisions were classified into thre

SUBMITTER: Luo Y 

PROVIDER: S-EPMC10154309 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature