FcRn inhibitors: a novel option for the treatment of myasthenia gravis.
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ABSTRACT:
SUBMITTER: Zhu LN
PROVIDER: S-EPMC10154512 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
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FcRn inhibitors: a novel option for the treatment of myasthenia gravis.
Zhu Li-Na LN Hou Hai-Man HM Wang Sai S Zhang Shuang S Wang Ge-Ge GG Guo Zi-Yan ZY Wu Jun J
Neural regeneration research 20230801 8
Myasthenia gravis is an acquired, humoral immunity-mediated autoimmune disease characterized by the production of autoantibodies that impair synaptic transmission at the neuromuscular junction. The intervention-mediated clearance of immunoglobulin G (IgG) was shown to be effective in controlling the progression of the disease. The neonatal Fc receptor (FcRn) plays a key role in prolonging the serum half-life of IgG. Antagonizing FcRn to prevent its binding to IgG can accelerate the catabolism of ...[more]
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