NALCN is a potential biomarker and therapeutic target in human cancers.

ABSTRACT: Background: Sodium leak channel non-selective (NALCN), known as a voltage-independent Na⁺ channel, is increasingly considered to play vital roles in tumorigenesis and metastasis of human cancers. However, no comprehensive pan-cancer analysis of NALCN has been conducted. Our study aims to explore the potential diagnostic, prognostic and therapeutic value of NALCN in human cancers. Methods: Through comprehensive application of datasets from Human Protein Atlas (HPA), The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), Enhanced Version of Tumor Immune Estimation Resource (TIMER2.0), Tumor and Immune System Interaction Database (TISIDB), The University of Alabama at Birmingham Cancer data analysis Portal (UALCAN), cBioPortal, GeneMANIA and Search Tool

SUBMITTER: He J 

PROVIDER: S-EPMC10154523 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature