Altered somatic hypermutation patterns in COVID-19 patients classifies disease severity.

ABSTRACT:

Introduction

The success of the human body in fighting SARS-CoV2 infection relies on lymphocytes and their antigen receptors. Identifying and characterizing clinically relevant receptors is of utmost importance.

Methods

We report here the application of a machine learning approach, utilizing B cell receptor repertoire sequencing data from severely and mildly infected individuals with SARS-CoV2 compared with uninfected controls.

Results

In contrast to previous studies, our approach successfully stratifies non-infected from infected individuals, as well as disease level of severity. The features that drive this classification are based on somatic hypermutation patterns, and point to alterations in the somatic hypermutation process in COVID-19 patients.

Discussion

SUBMITTER: Safra M 

PROVIDER: S-EPMC10154551 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature