Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With Schizophrenia.

ABSTRACT:

Background and hypothesis

Phosphodiesterase 10A (PDE10A) is a highly expressed enzyme in the basal ganglia, where cortical glutamatergic and midbrain dopaminergic inputs are integrated. Therapeutic PDE10A inhibition effects on schizophrenia have been reported previously, but the status of this molecule in the living patients with schizophrenia remains elusive. Therefore, this study aimed to investigate the central PDE10A status in patients with schizophrenia and examine its relationship with psychopathology, cognition, and corticostriatal glutamate levels.

Study design

This study included 27 patients with schizophrenia, with 5 antipsychotic-free cases, and 27 healthy controls. Positron emission tomography with [18F]MNI-659, a specific PDE10A radioligand, was employed to quan

SUBMITTER: Kubota M 

PROVIDER: S-EPMC10154699 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature