Insular and Striatal Correlates of Uncertain Risky Reward Pursuit in Schizophrenia.

ABSTRACT:

Background and hypothesis

Risk-taking in specific contexts can be beneficial, leading to rewarding outcomes. Schizophrenia is associated with disadvantageous decision-making, as subjects pursue uncertain risky rewards less than controls. However, it is unclear whether this behavior is associated with more risk sensitivity or less reward incentivization. Matching on demographics and intelligence quotient (IQ), we determined whether risk-taking was more associated with brain activation in regions affiliated with risk evaluation or reward processing.

Study design

Subjects (30 schizophrenia/schizoaffective disorder, 30 controls) completed a modified, fMRI Balloon Analogue Risk Task. Brain activation was modeled during decisions to pursue risky rewards and parametrically modeled

SUBMITTER: Purcell JR 

PROVIDER: S-EPMC10154703 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature