Controllability of Functional Brain Networks and Its Clinical Significance in First-Episode Schizophrenia.

ABSTRACT:

Background and hypothesis

Disrupted control of brain state transitions may contribute to the diverse dysfunctions of cognition, emotion, and behavior that are fundamental to schizophrenia. Control theory provides the rationale for evaluating brain state transitions from a controllability perspective, which may help reveal the brain mechanism for clinical features such as cognitive control deficits associated with schizophrenia. We hypothesized that brain controllability would be altered in patients with schizophrenia, and that controllability of brain networks would be related to clinical symptomatology.

Study design

Controllability measurements of functional brain networks, including average controllability and modal controllability, were calculated and compared between 125

SUBMITTER: Li Q 

PROVIDER: S-EPMC10154712 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature