Impact of Early-Life Factors on Risk for Schizophrenia and Bipolar Disorder.

ABSTRACT:

Background and hypothesis

Schizophrenia (SCZ) and bipolar disorder (BD) have shared genetic risk and clinical symptoms, yet the extent to which environmental risk factors are shared is not well known. We aimed to examine the associations of early-life environmental exposures with the risk of SCZ and BD.

Study design

We conducted a Swedish register-based nested case-control study using 4184 SCZ and 18 681 BD cases diagnosed 1988-2013, individually matched to 5 population-based controls by birth year, sex and birthplace. Conditional logistic regression was used to evaluate the risk of SCZ and BD by seasonality, severe prenatal infections, and perinatal factors.

Study results

Seasonality had similar patterns of risk for both disorders: Higher risk for births November-Dec

SUBMITTER: Robinson N 

PROVIDER: S-EPMC10154720 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature