Differential Effects of Clozapine and Haloperidol on the 40 Hz Auditory Steady State Response-mediated Phase Resetting in the Prefrontal Cortex of the Female Sprague Dawley Rat.

ABSTRACT:

Background

Neural synchrony at gamma frequency (~40 Hz) is important for information processing and is disrupted in schizophrenia. From a drug development perspective, molecules that can improve local gamma synchrony are promising candidates for therapeutic development.

Hypothesis

Given their differentiated clinical profile, clozapine, and haloperidol may have distinct effects on local gamma synchrony engendered by 40 Hz click trains, the so-called auditory steady-state response (ASSR).

Study design

Clozapine and haloperidol at doses known to mimic clinically relevant D2 receptor occupancy were evaluated using the ASSR in separate cohorts of female SD rats.

Results

Clozapine (2.5-10 mg/kg, sc) robustly increased intertrial phase coherence (ITC), across all dose

SUBMITTER: Ummear Raza M 

PROVIDER: S-EPMC10154723 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature