EFHD1, a novel mitochondrial regulator of tumor metastasis in clear cell renal cell carcinoma.

ABSTRACT: The biological function of many mitochondrial proteins in mechanistic detail has not been well investigated in clear cell renal cell carcinoma (ccRCC). A seven-mitochondrial-gene signature was generated by Lasso regression analysis to improve the prediction of prognosis of patients with ccRCC, using The Cancer Genome Atlas and Clinical Proteomic Tumor Analysis Consortium cohort. Among those seven genes, EFHD1 is less studied and its role in the progression of ccRCC remains unknown. The decreased expression of EFHD1 was validated in clinical samples and was correlated with unfavorable outcome. Overexpression of EFHD1 in ccRCC cells resulted in the reduction of mitochondrial Ca²⁺ , and the inhibition of cell migration and invasion in vitro and tumor metastasis in vivo. Mechanistic

SUBMITTER: Meng K 

PROVIDER: S-EPMC10154798 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature