Noninvasive Monitoring of Radiation-Induced Salivary Gland Vascular Injury.

ABSTRACT: Xerostomia is a common side effect of radiation therapy (RT) in patients with head and neck cancer. However, limited information is available on the temporal dynamics of parenchymal and vascular changes in salivary glands following RT. To address this gap in knowledge, we conducted experimental studies in mice employing ultrasound (US) with coregistered photoacoustic imaging (PAI) to noninvasively assess the early and late changes in salivary gland size, structure, vascularity, and oxygenation dynamics following RT. Multiparametric US-PAI of salivary glands was performed in immune-deficient and immune-competent mice before and after RT along with correlative sialometry and ex vivo histologic-immunohistochemical validation. US revealed reduction in gland volume and an early increase in vasc

SUBMITTER: Bolookat ER 

PROVIDER: S-EPMC10154916 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature