HSD3B1 is an oxysterol 3β-hydroxysteroid dehydrogenase in human placenta.

ABSTRACT: Most biologically active oxysterols have a 3β-hydroxy-5-ene function in the ring system with an additional site of oxidation at C-7 or on the side-chain. In blood plasma oxysterols with a 7α-hydroxy group are also observed with the alternative 3-oxo-4-ene function in the ring system formed by ubiquitously expressed 3β-hydroxy-Δ⁵-C₂₇-steroid oxidoreductase Δ⁵-isomerase, HSD3B7. However, oxysterols without a 7α-hydroxy group are not substrates for HSD3B7 and are not usually observed with the 3-oxo-4-ene function. Here we report the unexpected identification of oxysterols in plasma derived from umbilical cord blood and blood from pregnant women taken before delivery at 37+ weeks of gestation, of side-chain oxysterols with a 3-oxo-4-ene function but no 7α-hydro

SUBMITTER: Dickson A 

PROVIDER: S-EPMC10154939 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature