Myeloid-Derived Suppressor-Cell Dynamics Control Outcomes in the Metastatic Niche.

ABSTRACT: Myeloid-derived suppressor cells (MDSC) play a prominent role in the tumor microenvironment. A quantitative understanding of the tumor-MDSC interactions that influence disease progression is critical, and currently lacking. We developed a mathematical model of metastatic growth and progression in immune-rich tumor microenvironments. We modeled the tumor-immune dynamics with stochastic delay differential equations and studied the impact of delays in MDSC activation/recruitment on tumor growth outcomes. In the lung environment, when the circulating level of MDSCs was low, the MDSC delay had a pronounced impact on the probability of new metastatic establishment: blocking MDSC recruitment could reduce the probability of metastasis by as much as 50%. To predict patient-specific MDSC responses,

SUBMITTER: Kreger J 

PROVIDER: S-EPMC10155038 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature