Visualization of Activated Fibroblasts in Heart Failure with Preserved Ejection Fraction with [¹⁸F]AlF-NOTA-FAPI-04 PET/CT Imaging.

ABSTRACT: During the pathogenesis of heart failure with preserved ejection fraction (HFpEF), fibroblasts are activated and express the fibroblast activation protein (FAP). Targeted imaging of FAP can qualitatively and quantitatively assess the fibroblast activity. This study aimed to use [¹⁸F]AlF-NOTA-FAPI-04 (AlF = aluminum fluoride; NOTA = 1,4,7-triazacyclononane-1,4,7-triacetic acid; FAPI = FAP inhibitor) positron emission tomography/computed tomography (PET/CT) imaging to detect activated fibroblasts in a rat HFpEF model. The rat HfpEF model was established by feeding a high-fat diet plus l-NAME (N^ω-nitro-l-arginine methyl ester) for 10 weeks. Blood pressure, echocardiography, and [¹⁸F]AlF-NOTA-FAPI-04 PET/CT were used to assess the progression of HfpEF. T

SUBMITTER: Sun F 

PROVIDER: S-EPMC10155208 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature