Using Cluster Theory to Calculate the Experimental Structure Factors of Antibody Solutions.

ABSTRACT: Monoclonal antibody solutions are set to become a major therapeutic tool in the years to come, capable of targeting various diseases by clever design of their antigen binding site. However, the formulation of stable solutions suitable for patient self-administration typically presents challenges, as a result of the increase in viscosity that often occurs at high concentrations. Here, we establish a link between the microscopic molecular details and the resulting properties of an antibody solution through the characterization of clusters, which arise in the presence of self-associating antibodies. In particular, we find that experimental small-angle X-ray scattering data can be interpreted by means of analytical models previously exploited for the study of polymeric and colloidal objects, b

SUBMITTER: Skar-Gislinge N 

PROVIDER: S-EPMC10155212 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature