Hospitalized patients with positive antiphospholipid antibodies who have low complement levels are at increased risk for death-a retrospective cohort study.

ABSTRACT:

Purpose

To investigate whether low complement levels can predict worse outcomes in patients hospitalized with positive anti-phospholipid antibodies.

Methods

This was a retrospective cohort study. We obtained demographics, laboratory, and prognostic data of all consecutive patients hospitalized between 2007 and 2021, for whatever reason, with at least one positively abnormal anti-phospholipid antibody, who were also tested for complement levels (C3 or C4). We then compared the rates of long-term mortality, 1-year mortality, deep vein thrombosis, and pulmonary emboli between groups of low complement and normal complement levels. Multivariate analysis was used to control for levels of clinical and laboratory confounders.

Results

We identified 32,286 patients tested for a

SUBMITTER: Itelman E 

PROVIDER: S-EPMC10155279 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature