Diallyl disulfide alleviates hypercholesterolemia induced by a western diet by suppressing endoplasmic reticulum stress in apolipoprotein E-deficient mice.

ABSTRACT:

Background

The endoplasmic reticulum (ER) plays a pivotal role in maintaining cellular metabolic homeostasis. ER stress refers to the accumulation of misfolded proteins, which can trigger an unfolded protein response for survival or death in the cells. Diallyl disulfide (DADS), a major active compound in garlic, has many health benefits for patients with metabolic diseases, especially cardiovascular or fatty liver diseases. However, its role in attenuating hypercholesterolemia by suppressing ER stress remains unknown. Therefore, in this study, we determined whether DADS supplementation could reduce ER stress in apolipoprotein E-deficient (ApoE^-/-) mice fed a Western-type diet (WD).

Methods

ApoE^-/- mice were fed either a WD alone or a WD supplemented wit

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC10155326 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature