Dosage balance acts as a time-dependent selective barrier to subfunctionalization.

ABSTRACT:

Background

Gene duplication is an important process for genome expansion, sometimes allowing for new gene functions to develop. Duplicate genes can be retained through multiple processes, either for intermediate periods of time through processes such as dosage balance, or over extended periods of time through processes such as subfunctionalization and neofunctionalization.

Results

Here, we built upon an existing subfunctionalization Markov model by incorporating dosage balance to describe the interplay between subfunctionalization and dosage balance to explore selective pressures on duplicate copies. Our model incorporates dosage balance using a biophysical framework that penalizes the fitness of genetic states with stoichiometrically imbalanced proteins. These imbalanced st

SUBMITTER: Wilson AE 

PROVIDER: S-EPMC10155369 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature