Risk of second primary cancer among women in the Kaiser Permanente Breast Cancer Survivors Cohort.

ABSTRACT:

Background

Breast cancer survivors are living longer due to early detection and advances in treatment and are at increased risk for second primary cancers. Comprehensive evaluation of second cancer risk among patients treated in recent decades is lacking.

Methods

We identified 16,004 females diagnosed with a first primary stage I-III breast cancer between 1990 and 2016 (followed through 2017) and survived ≥ 1 year at Kaiser Permanente (KP) Colorado, Northwest, and Washington. Second cancer was defined as an invasive primary cancer diagnosed ≥ 12 months after the first primary breast cancer. Second cancer risk was evaluated for all cancers (excluding ipsilateral breast cancer) using standardized incidence ratios (SIRs), and a competing risk approach for cumulative incidence a

SUBMITTER: Ramin C 

PROVIDER: S-EPMC10155401 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature