Lipid metabolism in dopaminergic neurons influences light entrainment.

ABSTRACT: Dietary lipids, particularly omega-3 polyunsaturated fatty acids, are speculated to impact behaviors linked to the dopaminergic system, such as movement and control of circadian rhythms. However, the ability to draw a direct link between dopaminergic omega-3 fatty acid metabolism and behavioral outcomes has been limited to the use of diet-based approaches, which are confounded by systemic effects. Here, neuronal lipid metabolism was targeted in a diet-independent manner by manipulation of long-chain acyl-CoA synthetase 6 (ACSL6) expression. ACSL6 performs the initial reaction for cellular fatty acid metabolism and prefers the omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA). The loss of Acsl6 in mice (Acsl6^-/- ) depletes neuronal membranes of DHA content and result

SUBMITTER: Fernandez RF 

PROVIDER: S-EPMC10155601 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature