Gastric-type adenocarcinoma of the cervix: Clinical outcomes and genomic drivers.

ABSTRACT:

Objectives

Gastric-type endocervical adenocarcinoma (GEA) is a rare form of cervical cancer not associated with human papilloma virus (HPV) infection. We summarize our experience with GEA at a large cancer center.

Methods

Clinical and demographic information on all patients diagnosed with GEA between June 1, 2002 and July 1, 2019 was obtained retrospectively from clinical charts. Kaplan-Meier survival analysis was performed to describe progression-free survival (PFS) and overall survival (OS). Tumors from a subset of patients underwent next generation sequencing (NGS) analysis.

Results

A total of 70 women with GEA were identified, including 43 who received initial treatment at our institution: of these 4 (9%) underwent surgery alone, 15 (35%) underwent surgery followe

SUBMITTER: Ehmann S 

PROVIDER: S-EPMC10155605 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature