The association between antihypertensive treatment and serious adverse events by age and frailty: A cohort study.

ABSTRACT:

Background

Antihypertensives are effective at reducing the risk of cardiovascular disease, but limited data exist quantifying their association with serious adverse events, particularly in older people with frailty. This study aimed to examine this association using nationally representative electronic health record data.

Methods and findings

This was a retrospective cohort study utilising linked data from 1,256 general practices across England held within the Clinical Practice Research Datalink between 1998 and 2018. Included patients were aged 40+ years, with a systolic blood pressure reading between 130 and 179 mm Hg, and not previously prescribed antihypertensive treatment. The main exposure was defined as a first prescription of antihypertensive treatment. The primary o

SUBMITTER: Sheppard JP 

PROVIDER: S-EPMC10155987 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature