Monocular deprivation during the critical period alters neuronal tuning and the composition of visual circuitry.

ABSTRACT: Abnormal visual experience during a developmental critical period degrades cortical responsiveness. Yet how experience-dependent plasticity alters the response properties of individual neurons and composition of visual circuitry is unclear. Here, we measured with calcium imaging in alert mice how monocular deprivation (MD) during the developmental critical period affects tuning for binocularity, orientation, and spatial frequency for neurons in primary visual cortex. MD of the contralateral eye did not uniformly shift ocular dominance (OD) of neurons towards the fellow ipsilateral eye but reduced the number of monocular contralateral neurons and increased the number of monocular ipsilateral neurons. MD also impaired matching of preferred orientation for binocular neurons and reduced the pe

SUBMITTER: Brown TC 

PROVIDER: S-EPMC10155990 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature