Association between prenatal antimicrobial use and offspring attention deficit hyperactivity disorder.

ABSTRACT:

Background

Gut-brain cross-talk may play an important role in modulating neurodevelopment. Few studies have examined the association between antimicrobials that influence infant gut microbiota assemblage and attention deficit hyperactivity disorder (ADHD).

Objective

To examine the association between maternal prenatal antimicrobial use and ADHD in offspring at 10 years of age.

Methods

Data are from the Wayne County Health, Environment, Allergy and Asthma Longitudinal Study, a racially and socioeconomically diverse birth cohort in metropolitan Detroit, Michigan. Maternal antimicrobial use was extracted from the medical record. ADHD diagnoses were based on parental report at the 10-year study visit. Poisson regression models with robust error variance were used to calcu

SUBMITTER: Straughen JK 

PROVIDER: S-EPMC10156013 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature