Single-cell transcriptomics of the ocular anterior segment: a comprehensive review.

ABSTRACT: Elucidating the cellular and genetic composition of ocular tissues is essential for uncovering the pathophysiology of ocular diseases. Since the introduction of single-cell RNA sequencing (scRNA-seq) in 2009, vision researchers have performed extensive single-cell analyses to better understand transcriptome complexity and heterogeneity of ocular structures. This technology has revolutionized our ability to identify rare cell populations and to make cross-species comparisons of gene expression in both steady state and disease conditions. Importantly, single-cell transcriptomic analyses have enabled the identification of cell-type specific gene markers and signalling pathways between ocular cell populations. While most scRNA-seq studies have been conducted on retinal tissues, large-scale tra

SUBMITTER: Ahsanuddin S 

PROVIDER: S-EPMC10156079 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature