Development and application of a thin-film molecularly imprinted polymer for the measurement of mycophenolic acid in human plasma.

ABSTRACT:

Background

Mycophenolic acid (MPA) is used to suppress the immune response following organ transplantation; however, complex pharmacokinetic behavior and a large interpersonal variability necessitate therapeutic drug monitoring. To overcome the limitations of current sample preparation techniques, we present a novel thin-film molecularly imprinted polymer (TF-MIP) extraction device as part of a simple, sensitive, and fast method for analysis of MPA from human plasma.

Methods

Mycophenolic acid is extracted from plasma using a tailor-made TF-MIP that is subsequently desorbed into an organic solvent system compatible with mass spectrometry. The MIP yielded higher recovery of MPA relative to a corresponding non-imprinted polymer. The method allows for the determination of MPA in

SUBMITTER: Langille E 

PROVIDER: S-EPMC10156102 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature