Eigenvector centrality dynamics are related to Alzheimer's disease pathological changes in non-demented individuals.

ABSTRACT: Amyloid-β accumulation starts in highly connected brain regions and is associated with functional connectivity alterations in the early stages of Alzheimer's disease. This regional vulnerability is related to the high neuronal activity and strong fluctuations typical of these regions. Recently, dynamic functional connectivity was introduced to investigate changes in functional network organization over time. High dynamic functional connectivity variations indicate increased regional flexibility to participate in multiple subnetworks, promoting functional integration. Currently, only a limited number of studies have explored the temporal dynamics of functional connectivity in the pre-dementia stages of Alzheimer's disease. We study the associations between abnormal cerebrospinal fluid amylo

SUBMITTER: Lorenzini L 

PROVIDER: S-EPMC10156145 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature