BUB-1 and CENP-C recruit PLK-1 to control chromosome alignment and segregation during meiosis I in <i>C. elegans</i> oocytes.

ABSTRACT: Phosphorylation is a key post-translational modification that is utilised in many biological processes for the rapid and reversible regulation of protein localisation and activity. Polo-like kinase 1 (PLK-1) is essential for both mitotic and meiotic cell divisions, with key functions being conserved in eukaryotes. The roles and regulation of PLK-1 during mitosis have been well characterised. However, the discrete roles and regulation of PLK-1 during meiosis have remained obscure. Here, we used Caenorhabditis elegans oocytes to show that PLK-1 plays distinct roles in meiotic spindle assembly and/or stability, chromosome alignment and segregation, and polar body extrusion during meiosis I. Furthermore, by a combination of live imaging and biochemical analysis we identified the chromos

SUBMITTER: Taylor SJP 

PROVIDER: S-EPMC10156168 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature