Tissue fluidification promotes a cGAS-STING cytosolic DNA response in invasive breast cancer.

ABSTRACT: The process in which locally confined epithelial malignancies progressively evolve into invasive cancers is often promoted by unjamming, a phase transition from a solid-like to a liquid-like state, which occurs in various tissues. Whether this tissue-level mechanical transition impacts phenotypes during carcinoma progression remains unclear. Here we report that the large fluctuations in cell density that accompany unjamming result in repeated mechanical deformations of cells and nuclei. This triggers a cellular mechano-protective mechanism involving an increase in nuclear size and rigidity, heterochromatin redistribution and remodelling of the perinuclear actin architecture into actin rings. The chronic strains and stresses associated with unjamming together with the reduction of Lamin B1

SUBMITTER: Frittoli E 

PROVIDER: S-EPMC10156599 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature