Bacterial capsular polysaccharides with antibiofilm activity share common biophysical and electrokinetic properties.

ABSTRACT: Bacterial biofilms are surface-attached communities that are difficult to eradicate due to a high tolerance to antimicrobial agents. The use of non-biocidal surface-active compounds to prevent the initial adhesion and aggregation of bacterial pathogens is a promising alternative to antibiotic treatments and several antibiofilm compounds have been identified, including some capsular polysaccharides released by various bacteria. However, the lack of chemical and mechanistic understanding of the activity of these polymers limits their use to control biofilm formation. Here, we screen a collection of 31 purified capsular polysaccharides and first identify seven new compounds with non-biocidal activity against Escherichia coli and/or Staphylococcus aureus biofilms. We measure and theoretically

SUBMITTER: Bernal-Bayard J 

PROVIDER: S-EPMC10156666 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature