Oxytocin effects on amygdala reactivity to angry faces in males and females with antisocial personality disorder.

ABSTRACT: The amygdala is a key region in current neurocircuitry models of reactive aggression as it is crucially involved in detecting social threat and provocation. An increased amygdala reactivity to angry faces has been reported in aggression-prone individuals and the neuropeptide oxytocin (OT) could dampen anger-related amygdala reactivity in a number of mental disorders. One example is the antisocial personality disorder (ASPD) which has so far only been studied in limited numbers. To address the question whether OT can normalize amygdala hyperreactivity to emotional faces, we conducted a functional magnetic resonance imaging experiment with 20 men and 18 women with ASPD and 20 male and 20 female healthy control (HC) participants in a double-blind, randomized, placebo (PLC)-controlled within-s

SUBMITTER: Jeung-Maarse H 

PROVIDER: S-EPMC10156793 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature