25(OH)D-but not 1,25(OH)₂D-Is an independent risk factor predicting graft loss in stable kidney transplant recipients.

ABSTRACT:

Background

Vitamin D deficiency (VDD) or vitamin D insufficiency is common in kidney transplant recipients (KTRs). The impact of VDD on clinical outcomes in KTRs remain poorly defined and the most suitable marker for assessing vitamin D nutritional status in KTRs is unknown so far.

Methods

We conducted a prospective study including 600 stable KTRs (367 men, 233 women) and a meta-analysis to pool existing evidence to determine whether 25(OH)D or 1,25(OH)₂D predicted graft failure and all-cause mortality in stable KTRs.

Results

Compared with a higher 25(OH)D concentration, a low concentration of 25(OH)D was a risk factor for graft failure (HR 0.946, 95% CI 0.912-0.981, p = 0.003), whereas 1,25 (OH)₂D was not associated with the study end-poi

SUBMITTER: Zeng S 

PROVIDER: S-EPMC10156982 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature