Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome.

ABSTRACT:

Objective

We investigated effects of serum serotonin and interleukin 18 levels on suicidal ideation (SI) at acute and chronic phases of acute coronary syndrome (ACS).

Methods

Recent-onset 969 ACS patients were evaluated for serum serotonin and interleukin 18 levels; and SI by the "suicidal thoughts" item of the Montgomery-Åsberg Depression Rating Scale. After 1-year, 711 patients were re-evaluated for SI. Logistic regression models were used adjustment for potential covariates.

Results

Associations between serum interleukin 18 and SI at both phases were significant only in the lower serotonin group.

Conclusion

By evaluating serum serotonin and interleukin 18 levels, the clinical prediction of SI of ACS may be improved.

SUBMITTER: Kim JM 

PROVIDER: S-EPMC10157011 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature