Inflammatory Markers and Brain Volume in Patients with Post-traumatic Stress Disorder.

ABSTRACT:

Objective

Posttraumatic stress disorder (PTSD) is characterized by increased inflammatory processing and altered brain volume. In this study, we investigated the relationship between inflammatory markers and brain volume in patients with PTSD.

Methods

Forty-five patients with PTSD, and 70 healthy controls (HC) completed clinical assessments and self-reported psychopathology scales. Factors associated with inflammatory responses including brain-derived neurotrophic factor and four inflammatory biomarkers (C-reactive protein, cortisol, Interleukin-6, and homocysteine) and T1-magnetic resonance imaging of the brain were measured.

Results

In the PTSD group, cortisol level was significantly lower (t = 2.438, p = 0.046) than that of the HC. Cortisol level was

SUBMITTER: Yang C 

PROVIDER: S-EPMC10157021 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature