Microstructural and functional impairment of the basal ganglia in Wilson's disease: a multimodal neuroimaging study.

ABSTRACT:

Objectives

Magnetic susceptibility changes in brain MRI of Wilson's disease (WD) patients have been described in subcortical nuclei especially the basal ganglia. The objectives of this study were to investigate its relationship with other microstructural and functional alterations of the subcortical nuclei and the diagnostic utility of these MRI-related metrics.

Methods

A total of 22 WD patients and 20 healthy controls (HCs) underwent 3.0T multimodal MRI scanning. Susceptibility, volume, diffusion microstructural indices and whole-brain functional connectivity of the putamen (PU), globus pallidus (GP), caudate nucleus (CN), and thalamus (TH) were analyzed. Receiver operating curve (ROC) was applied to evaluate the diagnostic value of the imaging data. Correlation analysis wa

SUBMITTER: Su D 

PROVIDER: S-EPMC10157043 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature