Single-cell profiling of peripheral blood and muscle cells reveals inflammatory features of juvenile dermatomyositis.

ABSTRACT: Introduction: Juvenile dermatomyositis (JDM) is a rare yet serious childhood systemic autoimmune condition that primarily causes skin rashes and inflammatory myopathy of the proximal muscles. Although the associated immune response involves the innate and adaptive arms, a detailed analysis of the pertinent immune cells remains to be performed. This study aims to investigate the dynamic changes of cell type, cell composition and transcriptional profiles in peripheral blood and muscle tissues, and in order to clarify the involvement of immune cells in the pathogenesis of JDM and provide a theoretical reference for JDM. Methods: Single-cell RNA sequencing combined with bioinformatic analyses were used to investigate the dynamic changes in cell composition and transcriptional pro

SUBMITTER: Chen X 

PROVIDER: S-EPMC10157079 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature