A novel 25-ferroptosis-related gene signature for the prognosis of gliomas.

ABSTRACT:

Background

Ferroptosis is closely associated with cancer and is of great importance in the immune evasion of cancer. However, the relationship between ferroptosis and glioma is unclear.

Methods

We downloaded the expression profiles and clinical data of glioma from the GlioVis database and obtained the expression profiles of ferroptosis genes. A ferroptosis-related gene signature was developed for the prognosis of gliomas.

Results

We screened out prognostic ferroptosis genes, named ferroptosis-related genes, by the Cox regression method. Based on these genes, we used unsupervised clustering to obtain two different clusters; the principal component analysis algorithm was applied to determine the gene score of each patient, and then all the patients were classified into

SUBMITTER: Peng X 

PROVIDER: S-EPMC10157171 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature