Antisaccadic eye movements in middle-aged individuals with a family history of Alzheimer's disease.

ABSTRACT:

Background

Antisaccade is closely associated with cognitive ability in Alzheimer's disease (AD). However, studies regarding antisaccade in the early stages of AD are scarce. Considering that first-degree family history is a well-established risk factor for AD, we explored the influence of family history on the performance of antisaccade tasks in individuals with normal cognition.

Methods

In total, 44 participants (aged 50-66 years) with a family history of AD (FH+) and 44 age-, gender-, and educational level-matched controls (FH-) were enrolled in our study. After cognitive assessment using the Montreal Cognitive Assessment and Mini-mental State Examination, participants underwent antisaccade trials, and all parameters were recorded using an eye tracker.

Results

While

SUBMITTER: Peng A 

PROVIDER: S-EPMC10157194 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature