Comparison of different approaches to manage multi-site magnetic resonance spectroscopy clinical data analysis.

ABSTRACT:

Introduction

The effects caused by differences in data acquisition can be substantial and may impact data interpretation in multi-site/scanner studies using magnetic resonance spectroscopy (MRS). Given the increasing use of multi-site studies, a better understanding of how to account for different scanners is needed. Using data from a concussion population, we compare ComBat harmonization with different statistical methods in controlling for site, vendor, and scanner as covariates to determine how to best control for multi-site data.

Methods

The data for the current study included 545 MRS datasets to measure tNAA, tCr, tCho, Glx, and mI to study the pediatric concussion acquired across five sites, six scanners, and two different MRI vendors. For each metabolite, the site and

SUBMITTER: La PL 

PROVIDER: S-EPMC10157208 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature