Photo-responsive polymeric micelles for the light-triggered release of curcumin targeting antimicrobial activity.

ABSTRACT: Nanocarriers have been successfully used to solubilize, deliver, and increase the bioavailability of curcumin (CUR), but slow CUR release rates hinder its use as a topical photosensitizer in antimicrobial photodynamic therapy. A photo-responsive polymer (PRP) was designed for the light-triggered release of CUR with an effective light activation-dependent antimicrobial response. The characterization of the PRP was compared with non-responsive micelles comprising Pluronics™ P123 and F127. According to the findings, the PRP formed photo-responsive micelles in the nanometric scale (< 100 nm) with a lower critical micelle concentration (3.74 × 10^-4 M^-1, 5.8 × 10^-4 M^-1, and 7.2 × 10^-6 M^-1 for PRP, F127, P123, respectively, at 25°C

SUBMITTER: Trigo-Gutierrez JK 

PROVIDER: S-EPMC10157243 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature