In depth characterization of physicochemical critical quality attributes of a clinical drug-dendrimer conjugate.

ABSTRACT: A deep and detailed understanding of drug-dendrimer conjugates key properties is needed to define the critical quality attributes that affect drug product performance. The characterization must be executed both in the formulation media and in biological matrices. This, nevertheless, is challenging on account of a very limited number of suitable, established methods for characterizing the physicochemical properties, stability, and interaction with biological environment of complex drug-dendrimer conjugates. In order to fully characterize AZD0466, a drug-dendrimer conjugate currently under clinical development by AstraZeneca, a collaboration was initiated with the European Nanomedicine Characterisation Laboratory to deploy a state-of-the-art multi-step approach to measure physicochemical pro

SUBMITTER: Sonzini S 

PROVIDER: S-EPMC10157317 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature