Preclinical investigation of patient-derived cervical cancer organoids for precision medicine.

ABSTRACT:

Objective

Advanced cervical cancer is still difficult to treat and in the case of recurrent cancer, it is desirable to utilize personalized treatment rather than uniform treatment because the type of recurrence is different for each individual. Therefore, this study aimed to establish a patient-derived organoid (PDO) platform to determine the effects of chemotherapy, radiation therapy, and targeted therapy in cervical cancer.

Methods

We established organoids from 4 patients with various types of cervical cancer. The histopathological and gene profiles of these organoid models were compared to determine their characteristics and the maintenance of the patient phenotype. Each type of organoid was also subjected to anticancer drug screening and radiation therapy to evaluate its

SUBMITTER: Seol HS 

PROVIDER: S-EPMC10157333 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature