A prospective randomized multicenter trial for lymphadenectomy in early-stage ovarian cancer: LOVE study.

ABSTRACT:

Background

The Lymphadenectomy in Ovarian Neoplasms (LION) study revealed that systemic lymphadenectomy did not bring survival benefit for advanced ovarian cancer patients with clinically normal lymph nodes and was associated with a higher incidence of operative complications. However, there is no consensus on whether lymphadenectomy has survival benefit or not in early epithelial ovarian cancer (EOC).

Methods

We designed the LOVE study, a multicenter, randomized controlled, phase III trial to compare the efficacy and safety of comprehensive staging surgery with or without lymphadenectomy in stages IA-IIB EOC and fallopian tube carcinomas (FTC). The hypothesis is that the oncological outcomes provided by comprehensive staging surgery without lymphadenectomy are non-inferior

SUBMITTER: Deng T 

PROVIDER: S-EPMC10157337 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature