Magnitude and relevance of change in health-related quality of life in patients with vascular malformations treated with sirolimus.

ABSTRACT:

Introduction

Vascular malformations are rare congenital anomalies of the vascular system, which can involve the capillaries, veins, arteries, lymphatics, or a combination of vessel types. Patients with vascular malformations experience an impaired health-related quality of life (HRQoL) because of their symptoms (e.g., pain, swelling, and bleeding) and psychosocial distress. Sirolimus is an effective drug used in the medical treatment of these patients; however, relatively little is known about the effect of sirolimus on specific changes in the HRQoL domains and its magnitude.

Methods

The magnitude of change (effect size) following intervention is more informative to clinical practitioners than statistically significant but clinically unimportant changes; therefore, this stud

SUBMITTER: Harbers VEM 

PROVIDER: S-EPMC10157393 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature